Uryū Ishida is a bespectacled teenager of average height and slender build. He has straight, chin-length raven-colored hair framing both sides of his face, and is fair-skinned with blue eyes. In school, Uryū wears the respective school uniform along with a tie. When confronting Hollows, he typically dons white Quincy clothes, with blue stripes representing the Quincy cross, and a mantle.
Seventeen months after Aizen's defeat, Uryū's bangs hang mostly on the right-side of his face, and the rest hang behind his left ear, due to his glasses. After joining the Wandenreich, Uryū wears a white, double-breasted trench coat underneath a long white cape. The coat is fastened by three buttons emblazoned with the Quincy Zeichen on either side and a white belt with a silver buckle around the waist. Its shoulders are clasped to its neck, and the inside of the collar features a rectangular sigil on either side. Uryū also wears a pin shaped like a winged star circled by a halo on his right breast.
Uryū is generally quiet and solitary, but tries harder to act cool when other people are around. Uryū is a member of the handicrafts club at Karakura High School, and is highly skilled at sewing. While Uryū does not mind stitching things for his friends, his sense of design forces him to add unexpected designs. For example, when he makes new clothing for Chad and Orihime, he replaces the single red line of Chad's original shirt with a red cross, saying that it was better, and since he could not copy the three white dots on Orihime's shirt, he instead adds frilly lace and two flower-like buds at the bottom. Uryū has low blood pressure and hates procrastination. The other things he hates are quite odd: buttons (despite being an expert in sewing) and the word "haphazard." His favorite food is homemade mackerel miso stew. He likes Don Kanonji's television program "Bura-Rei" so much that he attends the live broadcast of the filming in Karakura Town.
He loves wearing a mantle, even though it serves no purpose other than to make him feel cooler, despite the fact that it hinders his movement, even keeping a spare with him. He has a tendency to say things melodramatically. Uryū has proven to be gullible at times. During an omake, he starts getting irritated at the fact that a weapon (a Zanpakutō in this case) has a will of own; Ichigo tricks him into thinking that Ginrei Kōjaku has actually materialized, to which Uryū sheds a happy tear. Uryū operates on a moral ethic known as the "Pride of the Quincy" and has a strong sense of justice. He is very chivalrous, stating that he enacts justice on men who abuse or treat women badly, leading him to attempt to defend Rukia Kuchiki from Renji Abarai when he and Byakuya Kuchiki came to the Human World to arrest her, and protects Orihime Inoue during their time in Soul Society. Uryū has a tendency to not use lethal force in battle, especially if he can win without doing so. Instead, he will simply incapacitate his opponent.